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Article

Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson's disease.

PloS one - 1 Jan 2012

Wey Margaret Chia-Ying, Fernandez Elizabeth, Martinez Paul Anthony, Sullivan Patricia, Goldstein David S, Strong Randy

Abstract excerpt

Previous studies have reported elevated levels of biogenic aldehydes in the brains of patients with Parkinson's disease (PD). In the brain, aldehydes are primarily detoxified by aldehyde dehydrogenases (ALDH). Reduced ALDH1 expression in surviving midbrain dopamine neurons has been reported in br...

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Identifiers

PMID: 22384032
DOI: 10.1371/journal.pone.0031522
PMCID: PMC3284575

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22384032-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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