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Article

Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity.

Pharmacogenetics - 1 Nov 2002

Isse Toyohi, Oyama Tsunehiro, Kitagawa Kyoko, Matsuno Koji, Matsumoto Akiko, Yoshida Akira, Nakayama Keiko, Nakayama Kei-Ichi, Kawamoto Toshihiro

Abstract excerpt

Aldehyde dehydrogenase (ALDH) 2 plays a major role in the detoxification of aldehyde and is known to be responsible for alcohol preference. A diminished enzyme activity due to mutation of the Aldh2 gene is associated with high alcohol sensitivity and a low alcohol tolerance in humans. The genomic background distinguishing an alcohol preference and avoidance in various inbred mouse strains is not clear. We created...

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Source

Identifiers

PMID: 12439222
DOI: 10.1097/00008571-200211000-00006

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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