Article
Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes.
Alcoholism, clinical and experimental research - 1 Feb 1991
Enomoto N, Takase S, Yasuhara M, Takada A
Abstract excerpt
In order to clarify the relationships between acetaldehyde (Ac-CHO) metabolism and low Km (mitochondrial) aldehyde dehydrogenase (ALDH2) genotypes, hepatic ALDH2 activity was determined and serial changes of blood Ac-CHO levels after ethanol administration were analyzed in the individuals homozygous for the normal ALDH2 genes, heterozygous for the normal and mutant ALDH2 genes, and homozygous for the mutant ALDH2...
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