Article
Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study.
Atherosclerosis - 1 Nov 2007
Volcik Kelly A, Ballantyne Christie M, Coresh Josef, Folsom Aaron R, Boerwinkle Eric
Abstract excerpt
OBJECTIVE: P-selectin (PSEL) and its ligand, P-selectin glycoprotein ligand-1 (PSGL-1), play key roles in both the inflammatory response and the atherosclerotic process, but there are conflicting results regarding the affect of PSEL and PSGL-1 gene variation on risk for cardiovascular and cerebrovascular disease. We tested the association of four PSEL and two PSGL-1 polymorphisms with incident coronary heart...
Topics
- Aged
- Atherosclerosis
- Cell Adhesion
- Coronary Artery Disease
- Genotype
- Haplotypes
- Humans
- Incidence
- Ischemia
- Membrane Glycoproteins
- Middle Aged