P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study.

doi:10.1016/j.atherosclerosis.2005.07.010

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Article

P-selectin Thr715Pro polymorphism predicts P-selectin levels but not risk of incident coronary heart disease or ischemic stroke in a cohort of 14595 participants: the Atherosclerosis Risk in Communities Study.

Atherosclerosis - 1 May 2006

Volcik Kelly A, Ballantyne Christie M, Coresh Josef, Folsom Aaron R, Wu Kenneth K, Boerwinkle Eric

Abstract excerpt

OBJECTIVE: Inflammation, characterized by the recruitment/adhesion of circulating leukocytes by cellular adhesion molecules, plays an important role in the pathogenesis of atherosclerosis. Genetic analyses of P-selectin, a key adhesion molecule in the progression of atherosclerosis, have provided...

Topics

Alleles
Biomarkers
Coronary Artery Disease
Disease Progression
Female
Follow-Up Studies
Gene Frequency
Genotype
Humans
Incidence
Male
Middle Aged
P-Selectin
Polymorphism, Genetic
Prospective Studies

Source

Open in PubMed

Identifiers

PMID: 16125711
DOI: 10.1016/j.atherosclerosis.2005.07.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-16125711-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Risk Factors

Stroke

United States