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Article

The Gly82Ser polymorphism in the receptor for advanced glycation endproducts increases the risk for coronary events in the general population.

Scientific reports - 21 May 2024

Grauen Larsen Helena, Sun Jiangming, Sjögren Marketa, Borné Yan, Engström Gunnar, Nilsson Peter, Orho-Melander Marju, Goncalves Isabel, Nilsson Jan, Melander Olle, Schiopu Alexandru

Abstract excerpt

The receptor for advanced glycation endproducts (RAGE) has pro-inflammatory and pro-atherogenic effects. Low plasma levels of soluble RAGE (sRAGE), a decoy receptor for RAGE ligands, have been associated with increased risk for major adverse coronary events (MACE) in the general population. We performed a genome-wide association study to identify genetic determinants of plasma sRAGE in 4338 individuals from the...

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Identifiers

PMID: 38773223
DOI: 10.1038/s41598-024-62385-5
PMCID: PMC11109115

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