Article
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.
The Journal of biological chemistry - 25 Feb 2005
Nilius Bernd, Prenen Jean, Tang Jisen, Wang Chunbo, Owsianik Grzegorz, Janssens Annelies, Voets Thomas, Zhu Michael X
Abstract excerpt
TRPM4, a Ca(2+)-activated cation channel of the transient receptor potential superfamily, undergoes a fast desensitization to Ca(2+). The mechanisms underlying the alterations in Ca(2+) sensitivity are unknown. Here we show that cytoplasmic ATP reversed Ca(2+) sensitivity after desensitization, whereas mutations to putative ATP binding sites resulted in faster and more complete desensitization. Phorbol...
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