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Article

Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G.

Journal of cellular physiology - 1 May 2006

Kwan Hiu-Yee, Huang Y, Yao Xiaoqiang

Abstract excerpt

There are two known phosphorylation-mediated inactivation mechanisms for TRPC3 channels. Protein kinase G (PKG) inactivates TRPC3 by direct phosphorylation on Thr-11 and Ser-263 of the TRPC3 proteins, and protein kinase C (PKC) inactivates TRPC3 by phosphorylation on Ser-712. In the present study, we explored the relationship between these two inactivation mechanisms of TRPC3. HEK cells were first stably...

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Source

Identifiers

PMID: 16331690
DOI: 10.1002/jcp.20567

Genes

TRPC3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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