Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of TRPC3 channels in ATP-induced Ca2+ signaling in principal cells of the inner medullary collecting duct.

American journal of physiology. Renal physiology - 1 Jul 2010

Goel Monu, Schilling William P

Abstract excerpt

The transient receptor potential channel TRPC3 is exclusively expressed in the apical membrane of principal cells of the collecting duct (CD) both in vivo and in the mouse CD cell line IMCD-3. Previous studies revealed that ATP-induced apical-to-basolateral transepithelial Ca(2+) flux across IMCD-3 monolayers is increased by overexpression of TRPC3 and attenuated by a dominant negative TRPC3 construct, suggesting...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anilides
Share to Kidney Medulla
Share to Kidney Tubules, Collecting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Video

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Share to Thapsigargin

Share to Thiadiazoles

Share to TRPC Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 20410214
DOI: 10.1152/ajprenal.00670.2009
PMCID: PMC2904168

Genes

TRPC3
SAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of TRPC3 channels in ATP-induced Ca2+ signaling in principal cells of the inner medullary collecting duct.PMID 20410214Read ↗

TRPC3: a multifunctional signaling molecule.Semantic proximity Read ↗

Canonical Transient Receptor Potential Channel (TRPC) 3 and TRPC6 Associate with Large-Conductance Ca2+-Activated K+ (BKCa) Channels: Role in BKCa Trafficking to the Surface of Cultured PodocytesSemantic proximity Read ↗

Evidence of a Role for Fibroblast Transient Receptor Potential Canonical 3 Ca2+ Channel in Renal Fibrosis.Semantic proximity Read ↗

TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes.Semantic proximity Read ↗

Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.Semantic proximity Read ↗

Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated Phosphorylation in Pancreatic β-Cells of the Line INS-1.Semantic proximity Read ↗

Protein kinase C can inhibit TRPC3 channels indirectly via stimulating protein kinase G.Semantic proximity Read ↗

Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density.Semantic proximity Read ↗

A calmodulin/inositol 1,4,5-trisphosphate (IP3) receptor-binding region targets TRPC3 to the plasma membrane in a calmodulin/IP3 receptor-independent process.Semantic proximity Read ↗

Expression of functional receptor-coupled TRPC3 channels in DT40 triple receptor InsP3 knockout cells.Semantic proximity Read ↗

TRPC3 controls agonist-stimulated intracellular Ca2+ release by mediating the interaction between inositol 1,4,5-trisphosphate receptor and RACK1.Semantic proximity Read ↗

Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.