Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Validation of High Throughput Screening Assays Against Three Subtypes of Ca <sub>v</sub> 3 T-Type Channels Using Molecular and Pharmacologic Approaches

1 Apr 2007

Abstract excerpt

T-type Ca(2+) channels encoded by voltage-gated Ca(2+) channel (Ca(v)) 3.1, 3.2, and 3.3 genes play important physiological roles and serve as therapeutic targets for neurological and cardiovascular disorders. Currently there is no selective T-channel blocker. To screen for such a blocker, we developed three stable cell lines expressing human recombinant Ca(v)3.1, 3.2, or 3.3 channels and then examined their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac electrophysiology and arrhythmias
Share to Ion channel regulation and function
Share to Neuroscience and Neural Engineering

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17477828
DOI: 10.1089/adt.2006.054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Validation of High Throughput Screening Assays Against Three Subtypes of Ca <sub>v</sub> 3 T-Type Channels Using Molecular and Pharmacologic ApproachesPMID 17477828Read ↗

Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels.Semantic proximity Read ↗

New screening system for selective blockers of voltage-gated K(+) channels using recombinant cell lines dying upon single action potential.Semantic proximity Read ↗

Phosphorylation states greatly regulate the activity and gating properties of Cav 3.1 T-type Ca2+ channels.Semantic proximity Read ↗

Exploring the function and pharmacotherapeutic potential of voltage-gated Ca2+ channels with gene knockout models.Semantic proximity Read ↗

<i>In Silico</i> identification and modelling of FDA-approved drugs targeting T-type calcium channelsSemantic proximity Read ↗

A hydrophobic residue in position 15 of the rP2X3 receptor slows desensitization and reveals properties beneficial for pharmacological analysis and high-throughput screening.Semantic proximity Read ↗

A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels.Semantic proximity Read ↗

G protein-mediated inhibition of Cav3.2 T-type channels revisited.Semantic proximity Read ↗

Functional importance of T-type voltage-gated calcium channels in the cardiovascular and renal system: news from the world of knockout mice.Semantic proximity Read ↗

Stimulated Phosphorylation of ERK in Mouse Kidney Mesangial Cells is Dependent Upon Expression of Cav3.1Semantic proximity Read ↗

Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels.Semantic proximity Read ↗

Molecular determinants of ion permeation and selectivity in inositol 1,4,5-trisphosphate receptor Ca2+ channels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.