Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels.

The Journal of biological chemistry - 24 Feb 2006

Kang Ho-Won, Park Jin-Yong, Jeong Seong-Woo, Kim Jin-Ah, Moon Hyung-Jo, Perez-Reyes Edward, Lee Jung-Ha

Abstract excerpt

Molecular cloning studies have revealed that heterogeneity of T-type Ca2+ currents in native tissues arises from the three isoforms of Ca(v)3 channels: Ca(v)3.1, Ca(v)3.2, and Ca(v)3.3. From pharmacological analysis of the recombinant T-type channels, low concentrations (<50 microM) of nickel were found to selectively block the Ca(v)3.2 over the other isoforms. To date, however, the structural element(s)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels, T-Type
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histidine

Share to Inhibitory Concentration 50

Share to Nickel

Share to RNA, Complementary

Share to Xenopus

Source

Identifiers

PMID: 16377633
DOI: 10.1074/jbc.M510197200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A molecular determinant of nickel inhibition in Cav3.2 T-type calcium channels.PMID 16377633Read ↗

Structural determinants of the high affinity extracellular zinc binding site on Cav3.2 T-type calcium channels.Semantic proximity Read ↗

Ins and outs of T-channel structure function.Semantic proximity Read ↗

Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability.Semantic proximity Read ↗

Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels.Semantic proximity Read ↗

Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG NeuronsSemantic proximity Read ↗

Validation of High Throughput Screening Assays Against Three Subtypes of Ca <sub>v</sub> 3 T-Type Channels Using Molecular and Pharmacologic ApproachesSemantic proximity Read ↗

G protein-mediated inhibition of Cav3.2 T-type channels revisited.Semantic proximity Read ↗

Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density.Semantic proximity Read ↗

Interaction with 14-3-3 proteins promotes functional expression of the potassium channels TASK-1 and TASK-3.Semantic proximity Read ↗

External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of alpha and gamma subunits and reducing channel open probability.Semantic proximity Read ↗

The molecular basis of voltage-gated Ca2+ channel diversity: is it time for T?Semantic proximity Read ↗

Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.