Article
Modulation of an inactivating human cardiac K+ channel by protein kinase C.
Circulation research - 1 Dec 1994
Murray K T, Fahrig S A, Deal K K, Po S S, Hu N N, Snyders D J, Tamkun M M, Bennett P B
Abstract excerpt
The transient outward current (ITO) is an important repolarizing component of the cardiac action potential. In native cardiac myocytes, ITO is modulated after activation of protein kinase C, although the molecular nature of this effect is not well understood. A channel recently cloned from human...
Topics
- Action Potentials
- Alkaloids
- Animals
- Benzophenanthridines
- Cell Membrane
- Cloning, Molecular
- Enzyme Activation
- Heart
- Humans
- Myocardium
- Oocytes
- Phenanthridines
- Phenotype
- Phorbol Esters
- Phosphorylation
- Potassium Channels
- Protein Kinase C
- Staurosporine