Article
Modulation of an inactivating human cardiac K+ channel by protein kinase C.
Circulation research - 1 Dec 1994
Murray K T, Fahrig S A, Deal K K, Po S S, Hu N N, Snyders D J, Tamkun M M, Bennett P B
Abstract excerpt
The transient outward current (ITO) is an important repolarizing component of the cardiac action potential. In native cardiac myocytes, ITO is modulated after activation of protein kinase C, although the molecular nature of this effect is not well understood. A channel recently cloned from human ventricular myocardium (Kv1.4, HK1) produces a rapidly inactivating K+ current, which has phenotypic similarities to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.