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Article

Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.

The Journal of physiology - 15 Jan 2006

Shimizu Shunichi, Yoshida Takashi, Wakamori Minoru, Ishii Masakazu, Okada Takaharu, Takahashi Masami, Seto Minoru, Sakurada Katsuhiko, Kiuchi Yuji, Mori Yasuo

Abstract excerpt

Mammalian homologues of Drosophila transient receptor potential (TRP) proteins are responsible for receptor-activated Ca(2+) influx in vertebrate cells. We previously reported the involvement of intracellular Ca(2+) in the receptor-mediated activation of mammalian canonical transient receptor potential 5 (TRPC5) channels. Here we investigated the role of calmodulin, an important sensor of changes in intracellular...

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Identifiers

PMID: 16284075
DOI: 10.1113/jphysiol.2005.097998
PMCID: PMC1464317

Genes

TRPC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.PMID 16284075Read ↗

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Phosphorylation of the Drosophila transient receptor potential ion channel is regulated by the phototransduction cascade and involves several protein kinases and phosphatases.Semantic proximity Read ↗

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