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Mycobacterium leprae Is Naturally Resistant to PA-824

27 Sept 2006

Abstract excerpt

Leprosy responds very slowly to the current multidrug therapy, and hence there is a need for novel drugs with potent bactericidal activity. PA-824 is a 4-nitroimidazo-oxazine that is currently undergoing phase I clinical trials for the treatment of tuberculosis. The activity of PA-824 against Mycobacterium leprae was tested and compared with that of rifampin in axenic cultures, macrophages, and two different...

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PMID: 17005816
DOI: 10.1128/aac.00488-06

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