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Article

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2006

Manjunatha Ujjini H, Boshoff Helena, Dowd Cynthia S, Zhang Liang, Albert Thomas J, Norton Jason E, Daniels Lacy, Dick Thomas, Pang Siew Siew, Barry Clifton E

Abstract excerpt

PA-824 is a promising new compound for the treatment of tuberculosis that is currently undergoing human trials. Like its progenitors metronidazole and CGI-17341, PA-824 is a prodrug of the nitroimidazole class, requiring bioreductive activation of an aromatic nitro group to exert an antitubercular effect. We have confirmed that resistance to PA-824 (a nitroimidazo-oxazine) and CGI-17341 (a nitroimidazo-oxazole)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16387854
DOI: 10.1073/pnas.0508392103
PMCID: PMC1326169

Genes

FGD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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