Article
Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy - 1 Sept 2015
Haver Hana L, Chua Adeline, Ghode Pramila, Lakshminarayana Suresh B, Singhal Amit, Mathema Barun, Wintjens René, Bifani Pablo
Abstract excerpt
Alleviating the burden of tuberculosis (TB) requires an understanding of the genetic basis that determines the emergence of drug-resistant mutants. PA-824 (pretomanid) is a bicyclic nitroimidazole class compound presently undergoing the phase III STAND clinical trial, despite lacking identifiable genetic markers for drug-specific resistant Mycobacterium tuberculosis. In the present study, we aimed to characterize...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.