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Article

Pyrazinoic Acid Inhibits a Bifunctional Enzyme in Mycobacterium tuberculosis

25 Apr 2017

Abstract excerpt

ABSTRACT Pyrazinamide (PZA), an indispensable component of modern tuberculosis treatment, acts as a key sterilizing drug. While the mechanism of activation of this prodrug into pyrazinoic acid (POA) by Mycobacterium tuberculosis has been extensively studied, not all molecular determinants that confer resistance to this mysterious drug have been identified. Here, we report how a new PZA resistance determinant, the...

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PMID: 28438933
DOI: 10.1128/aac.00070-17

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