Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

doi:10.1126/science.aag1006

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Article

Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420.

Science (New York, N.Y.) - 17 Mar 2017

Blondiaux Nicolas, Moune Martin, Desroses Matthieu, Frita Rosangela, Flipo Marion, Mathys Vanessa, Soetaert Karine, Kiass Mehdi, Delorme Vincent, Djaout Kamel, Trebosc Vincent, Kemmer Christian, Wintjens René, Wohlkönig Alexandre, Antoine Rudy, Huot Ludovic, Hot David, Coscolla Mireia, Feldmann Julia, Gagneux Sebastien, Locht Camille, Brodin Priscille, Gitzinger Marc, Déprez Benoit, Willand Nicolas, Baulard Alain R

Abstract excerpt

Antibiotic resistance is one of the biggest threats to human health globally. Alarmingly, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis have now spread worldwide. Some key antituberculosis antibiotics are prodrugs, for which resistance mechanisms are mainly driven by mutations in the bacterial enzymatic pathway required for their bioactivation. We have developed drug-like molecules...

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PMID: 28302858
DOI: 10.1126/science.aag1006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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