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Article

Mechanisms of resistance to delamanid, a drug for Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Jan 2018

Fujiwara Mamoru, Kawasaki Masanori, Hariguchi Norimitsu, Liu Yongge, Matsumoto Makoto

Abstract excerpt

Delamanid, a bicyclic nitroimidazooxazole, is effective against M. tuberculosis. Previous studies have shown that resistance to a bicyclic nitroimidazooxazine, PA-824, is caused by mutations in an F420-dependent bio-activation pathway. We investigated whether the same mechanisms are responsible for resistance to delamanid. Spontaneous resistance frequencies were determined using M. bovis BCG Tokyo (BCG) and M....

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PMID: 29523322
DOI: 10.1016/j.tube.2017.12.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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