Article
Mechanisms of resistance to delamanid, a drug for Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) - 1 Jan 2018
Fujiwara Mamoru, Kawasaki Masanori, Hariguchi Norimitsu, Liu Yongge, Matsumoto Makoto
Abstract excerpt
Delamanid, a bicyclic nitroimidazooxazole, is effective against M. tuberculosis. Previous studies have shown that resistance to a bicyclic nitroimidazooxazine, PA-824, is caused by mutations in an F420-dependent bio-activation pathway. We investigated whether the same mechanisms are responsible for resistance to delamanid. Spontaneous resistance frequencies were determined using M. bovis BCG Tokyo (BCG) and M....
Topics
- Antitubercular Agents
- Bacterial Proteins
- Chromatography, High Pressure Liquid
- DNA Mutational Analysis
- Drug Resistance, Multiple, Bacterial
- Genotype
- Isoniazid
- Microbial Sensitivity Tests
- Mutation
- Mycobacterium bovis