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11q13 amplification status and human papillomavirus in relation to p16 expression defines two distinct etiologies of head and neck tumours

26 Sept 2006

Abstract excerpt

Two distinct etiologies of head and neck squamous cell carcinoma (HNSCC) have been proposed, DNA damage owing to tobacco and alcohol exposure and human papillomavirus (HPV) oncogene-mediated transformation. Common genetic alterations in HNSCC include TP53 mutations, 11q13 amplification (amp) and CDKN2A/p16 mutations or promoter methlyation. However, in HPV+ HNSCC it is frequent to observe wild-type TP53 and...

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PMID: 17003776
DOI: 10.1038/sj.bjc.6603394

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