Article
p53 alterations and HPV infections are common in oral SCC: p53 gene mutations correlate with the absence of HPV 16-E6 DNA.
International journal of oncology - 1 Jan 1998
Penhallow J, Steingrimsdottir H, Elamin F, Warnakulasuriya S, Farzaneh F, Johnson N, Tavassoli M
Abstract excerpt
To examine the association between HPV infections and p53 gene aberrations, a panel of 28 oral squamous cell carcinomas (SCC) and 12 potentially malignant oral mucosal lesions were analysed for p53 mutations in exons 2-9. p53 protein was analysed by immunocytochemistry using DO7 antibody. The sam...
Topics
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- Cohort Studies
- DNA Primers
- DNA, Viral
- Female
- Genes, p53
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Mouth Neoplasms
- Mutation
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus Infections
- Polymerase Chain Reaction