Article
A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8.
International journal of cancer - 10 Nov 2003
Hafkamp Harriet C, Speel Ernst J M, Haesevoets Annick, Bot Fredrik J, Dinjens Winand N M, Ramaekers Frans C S, Hopman Anton H N, Manni Johannes J
Abstract excerpt
Besides well-known risk factors such as tobacco use and alcohol consumption, oncogenic human papillomavirus (HPV) infection also has recently been suggested to promote head and neck tumorigenesis. HPV is known to cause cancer by inactivation of cell cycle regulators p53 and pRb via expression of viral oncoproteins E6 and E7. This indicates that p53 mutations are not a prerequisite in HPV-induced tumor...
Topics
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Viral
- Exons
- Female
- Head and Neck Neoplasms
- Humans
- Immunohistochemistry
- Male
- Middle Aged