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Article

Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus.

Journal of the National Cancer Institute - 7 Jul 2004

Braakhuis Boudewijn J M, Snijders Peter J F, Keune Willem-Jan H, Meijer Chris J L M, Ruijter-Schippers Henrique J, Leemans C René, Brakenhoff Ruud H

Abstract excerpt

BACKGROUND: Transcriptionally active high-risk human papilloma viruses (HPVs), particularly HPV type 16 (HPV16), are found in a subset of head and neck squamous-cell carcinomas (HNSCCs). HPV16-associated carcinogenesis is mediated by expression of the viral E6 and E7 oncoproteins, which cause deregulation of the cell cycle by inactivating p53 and pRb, respectively. We tested the hypothesis that HPV-associated...

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Share to Carcinoma, Squamous Cell
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Loss of Heterozygosity

Share to Oncogene Proteins, Viral

Share to Papillomaviridae

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Source

Identifiers

PMID: 15240783
DOI: 10.1093/jnci/djh183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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