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Article

Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2008

Westra William H, Taube Janis M, Poeta M L, Begum Shanaz, Sidransky David, Koch Wayne M

Abstract excerpt

PURPOSE: Squamous cell carcinomas of the head and neck (HNSCC) often harbor p53 mutations, but p53 protein degradation by the viral oncoprotein E6 may supercede p53 mutations in human papillomavirus 16 (HPV16)-positive tumors. The prevalence of p53 mutations in HPV-positive HNSCCs is indeed lower, but in some tumors these alterations coexist. The purpose of this study was to discern whether HNSCCs differ in the...

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Share to Carcinoma, Squamous Cell
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Head and Neck Neoplasms

Share to Human papillomavirus 16

Share to Papillomavirus Infections

Share to Tissue Array Analysis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 18223210
DOI: 10.1158/1078-0432.CCR-07-1402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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