Article
p53 mutations in relation to human papillomavirus type 16 infection in squamous cell carcinomas of the head and neck.
International journal of cancer - 29 May 1997
Scholes A G, Liloglou T, Snijders P J, Hart C A, Jones A S, Woolgar J A, Vaughan E D, Walboomers J M, Field J K
Abstract excerpt
The relationship between human papillomavirus (HPV) type 16 infection and p53 gene mutations was investigated in squamous cell carcinomas of the head and neck (SCCHN). HPV was detected by general primer-mediated and type-specific PCR. Alterations in the p53 gene were investigated using single-strand conformation polymorphism and sequence analysis in 27 SCCHN, of which 12 were HPV 16-positive and 15 were...
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