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Article

SHP-1 variant proteins are absent in motheaten mice despite presence of splice variant transcripts with open reading frames.

Molecular immunology - 1 Jan 2000

Martin A, Tsui H W, Tsui F W

Abstract excerpt

Motheaten mice have a mutation that causes abnormal splicing of the SHP-1 gene producing transcripts that are out of frame. Thus, motheaten mice cannot produce normal SHP-1 protein. However, we have found that the SHP-1 locus in normal mice is expressed as multiple in-frame splice variant transcripts. We report here that the motheaten SHP-1 gene is likewise expressed in multiple spliced forms, two of which are in...

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PMID: 10698306
DOI: 10.1016/s0161-5890(99)00126-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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