Article

Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae

2022-06-26

Abstract excerpt

<h4>ABSTRACT</h4> PTPN6 encodes SHP1, a protein tyrosine phosphatase that has an essential role in immune cell function. SHP1 missense and splice site mutations are associated with neutrophilic dermatoses and emphysema in humans, which resembles the phenotype seen in mice that lack functional SHP1 partially. Complete lack of SHP1 function in mouse motheaten mutants leads to severe defects and lethality at 2-6 we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 16794905-49df-5902-bc7e-ba479a319253
DOI: 10.1101/2022.06.23.497321

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvaeDOI 10.1101/2022.06.23.497321Read

Shp1 function in myeloid cells.Semantic proximity Read

Investigations into the regulation and function of the SH2 domain-containing protein-tyrosine phosphatase, SHP-1.Semantic proximity Read

A differential gene expression study: Ptpn6 (SHP-1)-insufficiency leads to neutrophilic dermatosis-like disease (NDLD) in mice.Semantic proximity Read

Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis.Semantic proximity Read

Developmental biology of zebrafish myeloid cells.Semantic proximity Read

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects.Semantic proximity Read

Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten mice.Semantic proximity Read

Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humans.Semantic proximity Read

Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish.Semantic proximity Read

Peds1 deficiency in zebrafish results in myeloid cell apoptosis and exacerbated inflammationSemantic proximity Read

Live imaging of chronic inflammation caused by mutation of zebrafish Hai1.Semantic proximity Read

A zebrafish model of Poikiloderma with Neutropenia recapitulates the human syndrome hallmarks and traces back neutropenia to the myeloid progenitor.Semantic proximity Read