Article
The age incidence of chronic myeloid leukemia can be explained by a one-mutation model.
Proceedings of the National Academy of Sciences of the United States of America - 3 Oct 2006
Michor Franziska, Iwasa Yoh, Nowak Martin A
Abstract excerpt
Chronic myeloid leukemia (CML) is associated with the Philadelphia chromosome, which arises by a reciprocal translocation between chromosomes 9 and 22 and harbors the BCR-ABL fusion oncogene. It is unknown whether any other mutations are needed for the chronic phase of the disease. The CML incidence increases as a function of age with an exponent of approximately 3. A slope of 3 could indicate that there are two...
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