Article
A genetic association study of the functional A118G polymorphism of the human mu-opioid receptor gene in patients with acute and chronic pain.
Anesthesia and analgesia - 1 Oct 2006
Janicki Piotr K, Schuler Gregg, Francis David, Bohr Angela, Gordin Vitaly, Jarzembowski Tomasz, Ruiz-Velasco Victor, Mets Berend
Abstract excerpt
In this prospective, observational study we explored whether A118G single nucleotide polymorphism in the human mu-opioid receptor (MOR) gene could explain the inter-individual differences in opioid analgesic requirements in patients with acute postoperative pain and chronic pain. The frequency of the wild-type A118 MOR (major) and variant G118 MOR (minor) alleles in the subjects with chronic, noncancer pain (n =...
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