Article
Human opioid receptor A118G polymorphism affects intravenous patient-controlled analgesia morphine consumption after total abdominal hysterectomy.
Anesthesiology - 1 Aug 2006
Chou Wen-Ying, Wang Cheng-Haung, Liu Ping-Hsin, Liu Chien-Cheng, Tseng Chia-Chih, Jawan Bruno
Abstract excerpt
BACKGROUND: Animal and human studies indicate that genetics may contribute to the variability of morphine efficacy. A recent report suggested that cancer patients homozygous for the 118G allele caused by the single nucleotide polymorphism at nucleotide position 118 in the mu-opioid receptor gene require higher doses of morphine to relieve pain. The purpose of the current study was to investigate whether this...
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