Article
A118G single nucleotide polymorphism of human mu-opioid receptor gene influences pain perception and patient-controlled intravenous morphine consumption after intrathecal morphine for postcesarean analgesia.
Anesthesiology - 1 Sept 2008
Sia Alex T, Lim Yvonne, Lim Eileen C P, Goh Rachelle W C, Law Hai Yang, Landau Ruth, Teo Yik-Ying, Tan Ene Choo
Abstract excerpt
BACKGROUND: Previous studies have shown that genetic variability at position 118 of the human mu-opioid receptor gene altered patients' response to intravenous morphine. The purpose of this study was to investigate whether this polymorphism contributes to the variability in response to morphine for postcesarean analgesia. METHODS: After investigators obtained informed consent, 588 healthy women received 0.1 mg...
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