Article
The 118 A > G polymorphism in the human mu-opioid receptor gene may increase morphine requirements in patients with pain caused by malignant disease.
Acta anaesthesiologica Scandinavica - 1 Nov 2004
Klepstad P, Rakvåg T T, Kaasa S, Holthe M, Dale O, Borchgrevink P C, Baar C, Vikan T, Krokan H E, Skorpen F
Abstract excerpt
BACKGROUND: Dispositions for genes encoding opioid receptors may explain some variability in morphine efficacy. Experimental studies show that morphine and morphine-6-glucuronide are less effective in individuals carrying variant alleles caused by the 118 A > G polymorphism in the mu-opioid receptor gene (OPRM1). The purpose of the study was to investigate whether this and other genetic polymorphisms in OPRM1...
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