Article
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster.
Molecular and cellular biology - 1 Dec 2006
Balakireva Maria, Rossé Carine, Langevin Johanna, Chien Yu-chen, Gho Michel, Gonzy-Treboul Geneviève, Voegeling-Lemaire Stéphanie, Aresta Sandra, Lepesant Jean-Antoine, Bellaiche Yohanns, White Michael, Camonis Jacques
Abstract excerpt
Ral GTPase activity is a crucial cell-autonomous factor supporting tumor initiation and progression. To decipher pathways impacted by Ral, we have generated null and hypomorph alleles of the Drosophila melanogaster Ral gene. Ral null animals were not viable. Reduced Ral expression in cells of the sensory organ lineage had no effect on cell division but led to postmitotic cell-specific apoptosis. Genetic epistasis...
Topics
- Alleles
- Animals
- Apoptosis
- Cell Differentiation
- Cell Lineage
- Drosophila melanogaster
- Embryo, Nonmammalian
- Enzyme Activation
- Epistasis, Genetic
- GTP-Binding Proteins