Article
The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions.
Genes & development - 1 Jun 2005
Berset Thomas A, Hoier Erika Fröhli, Hajnal Alex
Abstract excerpt
Protein phosphorylation by kinases and the subsequent dephosphorylation by phosphatases are key mechanisms that regulate intracellular signal transduction during development. Here, we report the identification of the receptor protein tyrosine phosphatase DEP-1 as a negative regulator of the Caenorhabditis elegans EGF receptor. DEP-1 amplifies in the developing vulva and the excretory system the small differences...
Topics
- Animals
- Animals, Genetically Modified
- Base Sequence
- Caenorhabditis elegans
- Cell Cycle Proteins
- Cell Lineage
- Chromosomal Proteins, Non-Histone
- DNA Primers
- ErbB Receptors
- Green Fluorescent Proteins
- Mutation
- Nuclear Proteins
- Phosphoproteins
- Saccharomyces cerevisiae Proteins
- Signal Transduction