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Article

Negative-feedback regulation of proneural proteins controls the timing of neural precursor division.

Development (Cambridge, England) - 1 Sept 2008

Chang Pao-Ju, Hsiao Yun-Ling, Tien An-Chi, Li Yi-Chen, Pi Haiwei

Abstract excerpt

Neurogenesis requires precise control of cell specification and division. In Drosophila, the timing of cell division of the sensory organ precursor (SOP) is under strict temporal control. But how the timing of mitotic entry is determined remains poorly understood. Here, we present evidence that the timing of the G2-M transition is determined by when proneural proteins are degraded from SOPs. This process requires...

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PMID: 18701547
DOI: 10.1242/dev.021923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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