Article
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
The EMBO journal - 12 Dec 2007
Frische Ester W, Pellis-van Berkel Wendy, van Haaften Gijs, Cuppen Edwin, Plasterk Ronald H A, Tijsterman Marcel, Bos Johannes L, Zwartkruis Fried J T
Abstract excerpt
The small Ras-like GTPase Rap1 has been identified as a regulator of integrin activation and cadherin-mediated cell-cell contacts. Surprisingly, null mutants of RAP-1 in Caenorhabditis elegans are viable and fertile. In a synthetic lethal RNAi screen with C. elegans rap-1 mutants, the Ras-like GTPase ral-1 emerged as one of seven genes specifically required for viability. Depletion of exoc-8 and sec-5, encoding...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Movement
- Cytoskeletal Proteins
- Embryo, Nonmammalian
- Mutation
- Phenotype
- RNA Interference