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Article

Six and Eya promote apoptosis through direct transcriptional activation of the proapoptotic BH3-only gene egl-1 in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2010

Hirose Takashi, Galvin Brendan D, Horvitz H Robert

Abstract excerpt

The decision of a cell to undergo programmed cell death is tightly regulated during animal development and tissue homeostasis. Here, we show that the Caenorhabditis elegans Six family homeodomain protein C. elegans homeobox (CEH-34) and the Eyes absent ortholog EYA-1 promote the programmed cell death of a specific pharyngeal neuron, the sister of the M4 motor neuron. Loss of either ceh-34 or eya-1 function causes...

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Identifiers

PMID: 20713707
DOI: 10.1073/pnas.1010023107
PMCID: PMC2932601

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Source receipt: pubmed, retrieved 7 Sept 2026.

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