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Article

Evidence for unique association signals in SLE at the CD28-CTLA4-ICOS locus in a family-based study.

Human molecular genetics - 1 Nov 2006

Cunninghame Graham D S, Wong A K, McHugh N J, Whittaker J C, Vyse Timothy J

Abstract excerpt

CD28, CTLA4 (cytotoxic T lymphocyte-associated protein 4) and ICOS (inducible T cell co-stimulator) are good candidate genes for systemic lupus erythematosus (SLE) because of their role in regulating T cell activation. CTLA4 inhibits CD28-mediated T cell activation. CTLA4 is expressed on CD4+ and CD8+ activated T cells, and also B cells, but CD28 and ICOS are largely restricted to T cells. An interval...

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Source

Identifiers

PMID: 17000707
DOI: 10.1093/hmg/ddl395

Genes

CTLA4
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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