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Article

Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus.

Arthritis research & therapy - 30 May 2018

Julià Antonio, López-Longo Francisco Javier, Pérez Venegas José J, Bonàs-Guarch Silvia, Olivé Àlex, Andreu José Luís, Aguirre-Zamorano Mª Ángeles, Vela Paloma, Nolla Joan M, de la Fuente José Luís Marenco, Zea Antonio, Pego-Reigosa José María, Freire Mercedes, Díez Elvira, Rodríguez-Almaraz Esther, Carreira Patricia, Blanco Ricardo, Taboada Víctor Martínez, López-Lasanta María, Corbeto Mireia López, Mercader Josep M, Torrents David, Absher Devin, Marsal Sara, Fernández-Nebro Antonio

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci associated with SLE risk. To date, however, established loci account for less than 30% of the disease heritability and additional risk variants have yet to be identified. Here we performed a...

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Identifiers

PMID: 29848360
DOI: 10.1186/s13075-018-1604-1
PMCID: PMC5977506

Genes

ARHGAP27
CTLA4
GRB2
LAT2
SMYD3

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