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Article

DNA structural basis for fragility at peak III of BCL2 major breakpoint region associated with t(14;18) translocation.

Biochimica et biophysica acta. General subjects - 1 Mar 2018

Javadekar Saniya M, Yadav Rakhee, Raghavan Sathees C

Abstract excerpt

Maintaining genome integrity is crucial for normal cellular functions. DNA double-strand breaks (DSBs), when unrepaired, can potentiate chromosomal translocations. t(14;18) translocation involving BCL2 gene on chromosome 18 and IgH loci at chromosome 14, could lead to follicular lymphoma. Molecular basis for fragility of translocation breakpoint regions is an active area of investigation. Previously, formation of...

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Share to Chromosomal Instability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Chromosomes, Human, Pair 14

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Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 29246583
DOI: 10.1016/j.bbagen.2017.12.003

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA structural basis for fragility at peak III of BCL2 major breakpoint region associated with t(14;18) translocation.PMID 29246583Read ↗

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