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Article

Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma.

Nucleic acids research - 1 Feb 2011

Nambiar Mridula, Goldsmith G, Moorthy Balaji T, Lieber Michael R, Joshi Mamata V, Choudhary Bibha, Hosur Ramakrishna V, Raghavan Sathees C

Abstract excerpt

The t(14;18) translocation in follicular lymphoma is one of the most common chromosomal translocations. Most breaks on chromosome 18 are located at the 3'-UTR of the BCL2 gene and are mainly clustered in the major breakpoint region (MBR). Recently, we found that the BCL2 MBR has a non-B DNA chara...

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Share to Chromosome Breakpoints
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Magnetic Resonance, Biomolecular

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Source

Open in PubMed Open full text

Identifiers

PMID: 20880994
DOI: 10.1093/nar/gkq824
PMCID: PMC3035451

Genes

BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20880994-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Formation of a G-quadruplex at the BCL2 major breakpoint region of the t(14;18) translocation in follicular lymphoma.PMID 20880994Read ↗

DNA structural basis for fragility at peak III of BCL2 major breakpoint region associated with t(14;18) translocation.Semantic proximity Read ↗

Mechanism of Fragility at BCL2 Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal TranslocationSemantic proximity Read ↗

NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.Semantic proximity Read ↗

Double-strand break formation by the RAG complex at the bcl-2 major breakpoint region and at other non-B DNA structures in vitro.Semantic proximity Read ↗

The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.Semantic proximity Read ↗

Follicular lymphomas' BCL-2/IgH junctions contain templated nucleotide insertions: novel insights into the mechanism of t(14;18) translocationSemantic proximity Read ↗

The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas.Semantic proximity Read ↗

Diffusion-ordered nuclear magnetic resonance spectroscopy for analysis of DNA secondary structural elements.Semantic proximity Read ↗

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The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).Semantic proximity Read ↗

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.Semantic proximity Read ↗

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