Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protoporphyrin IX Interacts with Wild-type p53 Protein in Vitro and Induces Cell Death of Human Colon Cancer Cells in a p53-dependent and -independent Manner

30 Nov 2006

Abstract excerpt

Photodynamic therapy (PDT) of cancer is an alternative treatment for tumors resistant to chemo- and radiotherapy. It induces cancer cell death mainly through generation of reactive oxygen species by a laser light-activated photosensitizer. It has been suggested that the p53 tumor suppressor protein sensitizes some human cancer cells to PDT. However, there is still no direct evidence for this. We have demonstrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cancer Research and Treatments
Share to Photodynamic Therapy Research Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17135250
DOI: 10.1074/jbc.m608906200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protoporphyrin IX Interacts with Wild-type p53 Protein in Vitro and Induces Cell Death of Human Colon Cancer Cells in a p53-dependent and -independent MannerPMID 17135250Read ↗

Targeting of p53 and its homolog p73 by protoporphyrin IX.Semantic proximity Read ↗

Wild-type and mutant p53 differentially modulate miR-124/iASPP feedback following pohotodynamic therapy in human colon cancer cell lineSemantic proximity Read ↗

Mutant p53 drives cancer chemotherapy resistance due to loss of function on activating transcription of PUMASemantic proximity Read ↗

Wild-type p53 gene transfer into mutated p53 HT29 cells improves sensitivity to photodynamic therapy via induction of apoptosis.Semantic proximity Read ↗

p53-Dependent Anti-Proliferative and Pro-Apoptotic Effects of a Gold(I) N-Heterocyclic Carbene (NHC) Complex in Colorectal Cancer CellsSemantic proximity Read ↗

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.Semantic proximity Read ↗

The dual role of mutant p53 protein in chemosensitivity of human cancers.Semantic proximity Read ↗

Evidence for activation of mutated p53 by apigenin in human pancreatic cancer.Semantic proximity Read ↗

Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy.Semantic proximity Read ↗

Human pregnane X receptor compromises the function of p53 and promotes malignant transformationSemantic proximity Read ↗

Disruption of p53 in human cancer cells alters the responses to therapeutic agentsSemantic proximity Read ↗

Differential photosensitivity in wild-type and mutant p53 human colon carcinoma cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.