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Article

APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load.

AIDS (London, England) - 16 Jan 2010

Reddy Kavidha, Winkler Cheryl A, Werner Lise, Mlisana Koleka, Abdool Karim Salim S, Ndung'u Thumbi

Abstract excerpt

OBJECTIVES: In the absence of HIV-1 virion infectivity factor (Vif), cellular cytosine deaminases such as apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G) inhibit the virus by inducing hypermutations on viral DNA, among other mechanisms of action. We investigated the association of APOBEC3G mRNA levels and genetic variants on HIV-1 susceptibility, and early disease pathogenesis using...

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Identifiers

PMID: 19996938
DOI: 10.1097/QAD.0b013e3283353bba
PMCID: PMC3470914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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