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Article

Essential role for IL-10 in resistance to lipopolysaccharide-induced preterm labor in mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2006

Robertson Sarah A, Skinner Rebecca J, Care Alison S

Abstract excerpt

IL-10 is highly expressed in the uterus and placenta and is implicated in controlling inflammation-induced pathologies of pregnancy. To investigate the role of IL-10 in regulating preterm labor, the response of IL-10 null mutant mice to low-dose LPS in late gestation was evaluated. When IL-10 null mutant C57BL/6 (IL-10(-/-)) and control (IL-10(+/+)) mice were administered LPS on day 17 of pregnancy, the dose of...

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Source

Identifiers

PMID: 16982931
DOI: 10.4049/jimmunol.177.7.4888

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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