Article
Interleukin-6 is neither necessary nor sufficient for preterm labor in a murine infection model.
Journal of the Society for Gynecologic Investigation - 1 Oct 2003
Yoshimura Kazuaki, Hirsch Emmet
Abstract excerpt
OBJECTIVE: The aim of this study was to investigate the role of interleukin 6 (IL-6) in a murine model of bacterially induced preterm delivery. METHODS: On day 14.5 of a 19-20-day gestation, female mice underwent one of two interventions. In experiment 1, pregnant right uterine horns were injected at laparotomy with 0.5-20 microg of recombinant human IL-6 (rhIL-6). In experiment 2, IL-6-deficient (IL-6(-/-)) and...
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