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Article

The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss.

Journal of periodontal research - 1 Dec 2004

Sasaki Hajime, Okamatsu Yoshimasa, Kawai Toshihisa, Kent Ralph, Taubman Martin, Stashenko Philip

Abstract excerpt

OBJECTIVE: Interleukin-10 is an anti-inflammatory cytokine that reduces periapical bone loss, but its role in periodontal bone loss is unclear. In the present study, we tested the hypothesis that endogenous interleukin-10 is a potent suppressor of Porphyromonas gingivalis-induced alveolar bone loss in vivo. METHODS: Interleukin-10 knockout (-/-) and wild-type mice were inoculated intraorally with P. gingivalis....

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Source

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PMID: 15491348
DOI: 10.1111/j.1600-0765.2004.00760.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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