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Article

Thymidine kinase mutations conferring acyclovir resistance in herpes simplex type 1 recombinant viruses.

Antimicrobial agents and chemotherapy - 1 Nov 2006

Sergerie Yan, Boivin Guy

Abstract excerpt

Contributions of thymidine kinase (TK) mutations to acyclovir (ACV) resistance were evaluated in herpes simplex virus type 1 recombinant viruses generated using a set of overlapping cosmids and plasmids. Alterations in both conserved and nonconserved regions of the TK gene were shown to confer high levels of resistance to ACV.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16982796
DOI: 10.1128/AAC.00889-06
PMCID: PMC1635219

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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