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Article

Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir.

Journal of virology - 1 May 1997

Sasadeusz J J, Tufaro F, Safrin S, Schubert K, Hubinette M M, Cheung P K, Sacks S L

Abstract excerpt

In the majority of cases, the mechanism underlying the resistance to acyclovir (ACV) of herpes simplex viruses (HSVs) is thymidine kinase (TK) deficiency. Plaque isolates from eight ACV-resistant (ACVr) clinical isolates from AIDS patients, of which five reactivated, were sequenced to determine the genetic lesion within the tk gene conferring resistance and whether this may have correlated with reactivation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9094663
DOI: 10.1128/JVI.71.5.3872-3878.1997
PMCID: PMC191538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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