Article
Acyclovir-resistant, pathogenic herpesviruses.
Trends in microbiology - 1 Dec 1994
Coen D M
Abstract excerpt
In herpes simplex virus, the simplest path to resistance to the drug acyclovir is a mutation that knocks out the enzyme thymidine kinase. Such mutants are highly attenuated in mouse models of viral pathogenesis, but have been reported to be associated with severe disease in immunocompromised patients. This review discusses possible resolution of this paradox.
Topics
- Acyclovir
- Animals
- Drug Resistance, Microbial
- Herpes Simplex
- Humans
- Immunocompetence
- Immunocompromised Host
- Mice
- Mice, SCID
- Mutation
- Simplexvirus
- Thymidine Kinase