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Article

Characterization of herpes simplex viruses selected in culture for resistance to penciclovir or acyclovir.

Journal of virology - 1 Feb 2001

Sarisky R T, Quail M R, Clark P E, Nguyen T T, Halsey W S, Wittrock R J, O'Leary Bartus J, Van Horn M M, Sathe G M, Van Horn S, Kelly M D, Bacon T H, Leary J J

Abstract excerpt

Penciclovir (PCV), an antiherpesvirus agent in the same class as acyclovir (ACV), is phosphorylated in herpes simplex virus (HSV)-infected cells by the viral thymidine kinase (TK). Resistance to ACV has been mapped to mutations within either the TK or the DNA polymerase gene. An identical activation pathway, the similarity in mode of action, and the invariant cross-resistance of TK-negative mutants argue that the...

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Identifiers

PMID: 11160674
DOI: 10.1128/JVI.75.4.1761-1769.2001
PMCID: PMC114085

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Source receipt: pubmed, retrieved 7 Sept 2026.

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